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53 results

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Page 1
Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model.
Xu X, Sun Y, Cen X, Shan B, Zhao Q, Xie T, Wang Z, Hou T, Xue Y, Zhang M, Peng D, Sun Q, Yi C, Najafov A, Xia H. Xu X, et al. Protein Cell. 2021 Oct;12(10):769-787. doi: 10.1007/s13238-021-00858-3. Epub 2021 Jul 21. Protein Cell. 2021. PMID: 34291435 Free PMC article.
Importantly, we find that in the APP/PS1 mouse model of Alzheimer's disease (AD), activation of CMA by Hsc70 overexpression or Metformin potently reduces the accumulated brain Abeta plaque levels and reverses the molecular and behavioral AD phenotypes. ...
Importantly, we find that in the APP/PS1 mouse model of Alzheimer's disease (AD), activation of CMA by Hsc70 overexpression or Metfor …
Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease.
Hoffman JL, Faccidomo S, Kim M, Taylor SM, Agoglia AE, May AM, Smith EN, Wong LC, Hodge CW. Hoffman JL, et al. Int Rev Neurobiol. 2019;148:169-230. doi: 10.1016/bs.irn.2019.10.017. Epub 2019 Oct 23. Int Rev Neurobiol. 2019. PMID: 31733664 Free PMC article. Review.
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the most common cause of dementia in the United States. ...Bioinformatics identified the AD-associated proteins MAPT (Tau), amyloid beta precursor protein (APP), and presenilin-1 (PSEN-1) …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the most common cause of dementia in the United …
Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway.
Sriwastva MK, Deng ZB, Wang B, Teng Y, Kumar A, Sundaram K, Mu J, Lei C, Dryden GW, Xu F, Zhang L, Yan J, Zhang X, Park JW, Merchant ML, Egilmez NK, Zhang HG. Sriwastva MK, et al. EMBO Rep. 2022 Feb 3;23(3):e53365. doi: 10.15252/embr.202153365. Epub 2022 Jan 7. EMBO Rep. 2022. PMID: 34994476 Free PMC article.
As a proof of concept, we show that exosome-like nanoparticles (MBELNs) derived from edible mulberry bark confer protection against colitis in a mouse model by promoting heat shock protein family A (Hsp70) member 8 (HSPA8)-mediated activation of the AhR signaling pathway. …
As a proof of concept, we show that exosome-like nanoparticles (MBELNs) derived from edible mulberry bark confer protection against colitis …
Age-dependent accumulation of oligomeric SNCA/alpha-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA).
Ho PW, Leung CT, Liu H, Pang SY, Lam CS, Xian J, Li L, Kung MH, Ramsden DB, Ho SL. Ho PW, et al. Autophagy. 2020 Feb;16(2):347-370. doi: 10.1080/15548627.2019.1603545. Epub 2019 Apr 14. Autophagy. 2020. PMID: 30983487 Free PMC article.
Parkinson disease (PD) is an age-related neurodegenerative disorder associated with misfolded SNCA/alpha-synuclein accumulation in brain. ...Lysosomal clustering and accumulation of CMA-specific LAMP2A and HSPA8/HSC70 proteins were observed in aged mutant striatum a …
Parkinson disease (PD) is an age-related neurodegenerative disorder associated with misfolded SNCA/alpha-synuclein accumulation in br …
Psychotropics regulate Skp1a, Aldh1a1, and Hspa8 transcription--potential to delay Parkinson's disease.
Lauterbach EC. Lauterbach EC. Prog Neuropsychopharmacol Biol Psychiatry. 2013 Jan 10;40:236-9. doi: 10.1016/j.pnpbp.2012.08.021. Epub 2012 Oct 7. Prog Neuropsychopharmacol Biol Psychiatry. 2013. PMID: 23046827
Recently, the genes p19 S-phase kinase-associated protein 1A (SKP1), huntingtin interacting protein-2 (UBE2K), aldehyde dehydrogenase family 1 subfamily A1 (ALDH1A1), 19 S proteasomal protein PSMC4, and heat shock 70-kDa protein 8 (HSPA8) have been found to predict the ons …
Recently, the genes p19 S-phase kinase-associated protein 1A (SKP1), huntingtin interacting protein-2 (UBE2K), aldehyde dehydrogenase family …
A spinal muscular atrophy modifier implicates the SMN protein in SNARE complex assembly at neuromuscular synapses.
Kim JK, Jha NN, Awano T, Caine C, Gollapalli K, Welby E, Kim SS, Fuentes-Moliz A, Wang X, Feng Z, Sera F, Takeda T, Homma S, Ko CP, Tabares L, Ebert AD, Rich MM, Monani UR. Kim JK, et al. Neuron. 2023 May 3;111(9):1423-1439.e4. doi: 10.1016/j.neuron.2023.02.004. Epub 2023 Mar 1. Neuron. 2023. PMID: 36863345
Reduced survival motor neuron (SMN) protein triggers the motor neuron disease, spinal muscular atrophy (SMA). Restoring SMN prevents disease, but it is not known how neuromuscular function is preserved. ...Concomitantly, synaptic vesicular SNARE complex formation, w …
Reduced survival motor neuron (SMN) protein triggers the motor neuron disease, spinal muscular atrophy (SMA). Restoring SMN prevents …
The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain.
Issa AR, Sun J, Petitgas C, Mesquita A, Dulac A, Robin M, Mollereau B, Jenny A, Chérif-Zahar B, Birman S. Issa AR, et al. Autophagy. 2018;14(11):1898-1910. doi: 10.1080/15548627.2018.1491489. Epub 2018 Aug 10. Autophagy. 2018. PMID: 29989488 Free PMC article.
Alterations in autophagy processes, including macroautophagy and chaperone-mediated autophagy (CMA), have been described in Parkinson disease (PD). CMA is a selective autophagic process that depends on LAMP2A (lysosomal-associated membrane protein 2A), a mammal and bird-sp …
Alterations in autophagy processes, including macroautophagy and chaperone-mediated autophagy (CMA), have been described in Parkinson dis …
Proximity proteomics of C9orf72 dipeptide repeat proteins identifies molecular chaperones as modifiers of poly-GA aggregation.
Liu F, Morderer D, Wren MC, Vettleson-Trutza SA, Wang Y, Rabichow BE, Salemi MR, Phinney BS, Oskarsson B, Dickson DW, Rossoll W. Liu F, et al. Acta Neuropathol Commun. 2022 Feb 14;10(1):22. doi: 10.1186/s40478-022-01322-x. Acta Neuropathol Commun. 2022. PMID: 35164882 Free PMC article.
While evidence from cellular and animal models supports a toxic gain-of-function of pathologic poly-GA, poly-GR, and poly-PR aggregates in promoting deposition of TDP-43 pathology and neurodegeneration in affected brain areas, the relative contribution of DPRs to th …
While evidence from cellular and animal models supports a toxic gain-of-function of pathologic poly-GA, poly-GR, and poly-PR a …
Torsins: not your typical AAA+ ATPases.
Rose AE, Brown RS, Schlieker C. Rose AE, et al. Crit Rev Biochem Mol Biol. 2015;50(6):532-49. doi: 10.3109/10409238.2015.1091804. Epub 2015 Oct 13. Crit Rev Biochem Mol Biol. 2015. PMID: 26592310 Free PMC article. Review.
Here, we provide a comprehensive overview of the Torsin system in metazoans, discuss functional clues obtained from various model systems and organisms and provide a phylogenetic and structural analysis of Torsins and their regulatory cofactors in relation to disease-causa …
Here, we provide a comprehensive overview of the Torsin system in metazoans, discuss functional clues obtained from various model systems an …
Torsin ATPases: structural insights and functional perspectives.
Laudermilch E, Schlieker C. Laudermilch E, et al. Curr Opin Cell Biol. 2016 Jun;40:1-7. doi: 10.1016/j.ceb.2016.01.001. Epub 2016 Jan 21. Curr Opin Cell Biol. 2016. PMID: 26803745 Free PMC article. Review.
These findings profoundly change our molecular view of the Torsin machinery and rationalize several human mutations in TorsinA or LAP1 leading to congenital disorders, symptoms of which have recently been recapitulated in mouse models. Here, we review these recent advances …
These findings profoundly change our molecular view of the Torsin machinery and rationalize several human mutations in TorsinA or LAP1 leadi …
53 results